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Home > Immune history profoundly affects broadly protective B cell responses to influenza

Friday, December 4, 2015 - 12:49
Original: 
Immune history profoundly affects broadly protective B cell responses to influenza [1]
Source 
Scientific literature [2]
Target 
Healthcare Professionals [3]
Topic 
Vaccination [4]
Tags 
Vaccine [5]
flu [6]
influenza [7]

Andrews SF, Huang Y, Kaur K, Popova LI, Ho IY, Pauli NT, et al. Sci Transl Med. 2015 Dec 2;7(316):316ra192. 

A universal flu vaccine has been a Sisyphean trial—despite successful seasonal vaccines, the immune system has to start over with newly mutated influenza strains. Now, Andrews et al. look in depth at the B cell response to the pandemic 2009 H1N1 vaccine over time. They found that people with low titers of preexisting antibodies were more likely to generate a broadly reactive response that targets the more conserved hemagglutinin (HA) stalk region, whereas those with higher levels of preexisting antibodies responded by targeting the more variable HA head. The preexisting head antibodies were immunodominant and prevented clear access to the stalk. These data suggest that exposure history is critical in designing a universal flu vaccine.

Link to full text [1]

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Action plan on Science in Society related issues in Epidemics and Total pandemics
European Commission
This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 612236.

Source URL: http://www.asset-scienceinsociety.eu/resources/scientific-literature/immune-history-profoundly-affects-broadly-protective-b-cell

Links
[1] http://stm.sciencemag.org/content/7/316/316ra192
[2] http://www.asset-scienceinsociety.eu/resources/scientific-literature
[3] http://www.asset-scienceinsociety.eu/target/healthcare-professionals
[4] http://www.asset-scienceinsociety.eu/topic/vaccination
[5] http://www.asset-scienceinsociety.eu/tags/vaccine
[6] http://www.asset-scienceinsociety.eu/tags/flu
[7] http://www.asset-scienceinsociety.eu/tags/influenza