A debate is ongoing if Olympic Games should be cancelled, moved or delayed because of the Public Health Emergency of International Concern declared by WHO on 1st February 2016 on microcephaly in Brazil, which is being proven to be associated with Zika infection. On May 25th, 150 experts in bioethics, public health and social sciences signed an open letter to the WHO, asking to skip the Games, in order to avoid a further spread of the epidemic.